Meld score 5 year survival3/16/2023 ![]() 8, 9, 10 According to the results of these studies, the use of serum sodium in the assessment of severity of cirrhosis has been recommended. In this regard, several recent studies have shown that serum sodium concentration is a good marker of prognosis in patients awaiting transplantation. 4– 7 Therefore, there is need for improvement of the MELD score. Nevertheless, several studies, as well as clinical observation, indicate that some subsets of patients with cirrhosis may have high mortality despite low MELD scores. 1– 3 This model, which includes variables related to both liver and renal function, was implemented in the USA in 2002 and is currently being used in many countries to classify patients with cirrhosis awaiting transplantation according to the severity of their liver disease. The model for end-stage liver disease (MELD) score is the method most widely used for organ allocation in liver transplantation. MELD, model for end-stage liver disease.Larger studies are needed to determine whether the addition of serum sodium to MELD can improve its prognostic accuracy. The addition of serum sodium did not significantly improve the accuracy of the MELD score in the prediction of survival at 3 and 12 months.Ĭonclusion: In patients with cirrhosis awaiting liver transplantation, serum sodium and MELD were found to be independent predictors of survival. The area under the ROC curves for serum sodium and MELD score was not significantly different both at 3 months (0.83 vs 0.79, respectively) and at 12 months (0.70 vs 0.77, respectively). Low serum sodium was associated with an increased risk of death in all subpopulations of patients with cirrhosis categorised according to the major complication developed before listing. Results: The MELD score and serum sodium concentration were the only independent predictors of survival at 3 and 12 months after listing. Accuracy of prognostic variables was analysed by receiver operating characteristic (ROC) curves. Variables obtained at the time of listing were analysed for prognostic value using multivariable analysis. The end-point was survival at 3 and 12 months before transplantation. Patients and methods: 308 consecutive patients with cirrhosis listed for transplantation during a 5-year period were included in the study. The aim of the present study was to assess the prognostic value of serum sodium in the prediction of survival at 3 and 12 months after listing in patients with cirrhosis awaiting liver transplantation, and to compare its predictive value with that of the MELD score. Correspondence to: Pere Ginès MD, Liver Unit, Hospital Clínic de Barcelona, C/Villarroel 170, 08036, Barcelona, Spain pginesclinic.ub.esīackground/Aims: Serum sodium predicts prognosis in cirrhosis and may improve the prognostic accuracy of the model for end-stage liver disease (MELD) score, but the available information is limited.3Department of Biostatistics, Hospital Clínic, Universitat de Barcelona, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas y Digestivas (CIBEREHD) and Centro de Investigaciones Biomédicas Esther Koplowitz (CIBEK), Barcelona, Spain.2Department of Surgery, Hospital Clínic, Universitat de Barcelona, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas y Digestivas (CIBEREHD) and Centro de Investigaciones Biomédicas Esther Koplowitz (CIBEK), Barcelona, Spain.1Liver Unit, Hospital Clínic, Universitat de Barcelona, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), CIBER de Enfermedades Hepáticas y Digestivas (CIBEREHD) and Centro de Investigaciones Biomédicas Esther Koplowitz (CIBEK), Barcelona, Spain.
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